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Smart Investors Daily
SP

NASDAQ · SPRO

Spero Therapeutics, Inc.

Healthcare · Biotechnology

$1.11

Down-$0.06 (-5.13%)

Updated Oct 30, 2026, 2:49 AM

SID Score

3.0/10

Composite research score

Smart Money

—

Institutional and insider signal

Market cap
132.38M
P/E ratio
-3.02
Dividend yield
0.00%
52-week range
$1.04 – $3.08
Volume
209.73K
Avg. volume
638.96K

Price performance · SPRO

SPRO price history

1M range · 21 trading sessions · Daily adjusted prices

Prices through Oct 29, 2026

SPRO closed at $1.11 after 21 trading sessions, down 11.90% for the selected period.

Last close
$1.11
Period change
-11.90%
Period low
$1.07
Period high
$1.26
Daily close
View OHLC price history
SPRO OHLC price history, latest 40 sessions
DateOpenHighLowCloseVolume
Oct 29, 2026$1.18$1.18$1.11$1.11209.73K
Oct 28, 2026$1.18$1.18$1.12$1.17338.85K
Oct 27, 2026$1.08$1.14$1.04$1.14507.85K
Oct 26, 2026$1.10$1.11$1.06$1.07513.87K
Oct 23, 2026$1.13$1.13$1.10$1.11316.55K
Oct 22, 2026$1.16$1.17$1.13$1.13203.27K
Oct 21, 2026$1.21$1.22$1.165$1.17265.71K
Oct 20, 2026$1.12$1.24$1.11$1.22679.28K
Oct 19, 2026$1.09$1.13$1.09$1.12203.03K
Oct 16, 2026$1.14$1.17$1.09$1.10361.28K
Oct 15, 2026$1.12$1.14$1.11$1.13233.83K
Oct 14, 2026$1.15$1.17$1.11$1.12697.61K
Oct 13, 2026$1.19$1.2027$1.15$1.15272.49K
Oct 12, 2026$1.20$1.22$1.165$1.18414.26K
Oct 9, 2026$1.14$1.21$1.13$1.20439.18K
Oct 8, 2026$1.20$1.22$1.13$1.14719.79K
Oct 7, 2026$1.19$1.19$1.16$1.17236.67K
Oct 6, 2026$1.21$1.236$1.18$1.19347.57K
Oct 5, 2026$1.17$1.20$1.15$1.16942.72K
Oct 2, 2026$1.26$1.266$1.1705$1.19906.92K
Oct 1, 2026$1.22$1.31$1.195$1.261.04M

Latest SPRO news

The latest Smart Investors Daily articles mentioning SPRO.

SPRO research

Overview

Company profile and research snapshot.

Company profile

Spero Therapeutics Inc is a clinical-stage biopharmaceutical firm. It focuses on identifying, developing, and commercializing novel treatments for MDR (Multi-drug-resistant) bacterial infections and rare diseases. The company's product candidate, tebipenem pivoxil hydrobromide or tebipenem HBr, is designed to be an oral carbapenem-class antibiotic for use in adults to treat MDR Gram-negative infections. It is also developing SPR720, a novel oral antibiotic designed for the treatment of a rare, orphan disease caused by pulmonary non-tuberculous mycobacterial infections, or NTM disease. Besides, it is also focused on SPR206, a next-generation polymyxin investigational product candidate being developed as an IV-administered medicine to treat MDR Gram-negative infections in the hospital.

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Analyst outlook

Consensus and target data currently published for this company.

Consensus
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Average target
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Implied upside
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Analysts
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SPRO recent ratings
DateFirmRatingTarget
Oct 28, 2026Cantor FitzgeraldOverweight—
Sep 14, 2026HC Wainwright & Co.Buy—
Jan 30, 2025HC Wainwright & Co.Buy—
Dec 20, 2024Evercore ISI GroupIn-Line—
Dec 2, 2024HC Wainwright & Co.Buy—
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News briefing

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AI research layers

Interpretive context generated from the platform’s current data sources.

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