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Smart Investors Daily
SI

NASDAQ · SION

Sionna Therapeutics, Inc.

Healthcare · Biotechnology

$3.73

Down-$0.08 (-2.26%)

Updated Nov 3, 2026, 8:22 PM

SID Score

3.0/10

Composite research score

Smart Money

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Institutional and insider signal

Market cap
1.86B
P/E ratio
-31.26
Dividend yield
0.00%
52-week range
$3.55 – $54.97
Volume
656.79K
Avg. volume
293.9K

Price performance · SION

SION price history

1M range · 21 trading sessions · Daily adjusted prices

Prices through Nov 2, 2026

SION closed at $3.73 after 21 trading sessions, down 23.09% for the selected period.

Last close
$3.73
Period change
-23.09%
Period low
$3.60
Period high
$4.90
Daily close
View OHLC price history
SION OHLC price history, latest 40 sessions
DateOpenHighLowCloseVolume
Nov 2, 2026$3.91$3.935$3.65$3.73656.79K
Oct 30, 2026$3.96$4.0499$3.76$3.87534.38K
Oct 29, 2026$4.05$4.16$3.97$4.00578.36K
Oct 28, 2026$3.85$4.155$3.78$4.04953K
Oct 27, 2026$3.68$3.905$3.63$3.871M
Oct 26, 2026$3.58$3.74$3.57$3.69614.22K
Oct 23, 2026$3.75$3.816$3.55$3.60918.2K
Oct 22, 2026$3.87$3.97$3.6414$3.801.59M
Oct 21, 2026$4.20$4.31$3.86$3.871.56M
Oct 20, 2026$4.06$4.30$4.02$4.151.07M
Oct 19, 2026$3.93$4.11$3.84$4.011.17M
Oct 16, 2026$4.06$4.06$3.775$3.891.49M
Oct 15, 2026$4.15$4.30$4.0201$4.08944.61K
Oct 14, 2026$4.30$4.40$3.9301$4.091.5M
Oct 13, 2026$4.69$4.795$4.365$4.38790.63K
Oct 12, 2026$4.89$4.93$4.675$4.69692.61K
Oct 9, 2026$4.93$5.12$4.83$4.90633.56K
Oct 8, 2026$4.78$4.97$4.65$4.90915.6K
Oct 7, 2026$4.68$4.87$4.61$4.82880.22K
Oct 6, 2026$4.88$4.88$4.52$4.751.26M
Oct 5, 2026$4.95$4.96$4.63$4.851.1M

Latest SION news

The latest Smart Investors Daily articles mentioning SION.

SION research

Overview

Company profile and research snapshot.

Company profile

Sionna Therapeutics Inc is a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for cystic fibrosis (CF) patients by developing novel medicines that normalize the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein to deliver clinically meaningful benefit to CF patients. CF is a progressive and life-threatening genetic disease caused by inherited mutations in the CFTR gene, which heads to insufficient CFTR function. The Company is managed as one operating segment focused on the research and development of cystic fibrosis therapies.

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Analyst outlook

Consensus and target data currently published for this company.

Consensus
—
Average target
$34.50
Implied upside
—
Analysts
—
SION recent ratings
DateFirmRatingTarget
Sep 15, 2026WedbushNeutral—
Aug 11, 2026GuggenheimNeutral—
Aug 11, 2026WedbushNeutral—
Aug 10, 2026BTIGNeutral—
Aug 7, 2026GuggenheimBuy—
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News briefing

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Yahoo · Oct 8, 2026

Sionna Therapeutics to Present Data at the 2026 North American Cystic Fibrosis Conference

Previously disclosed post hoc PreciSION CF analyses of SION-719 support advancement of SION-451 + SION-2222 into the AscenSION CF Phase 2a proof-of-concept trial New preclinical data evaluating NBD1 stabilizers in combination with other CFTR modulators across F508del genotype groups demonstrated the potential of NBD1 stabilizer-based combinations to benefit a broad population of people with CF WALTHAM, Mass., Oct. 08, 2026 (GLOBE NEWSWIRE) -- Sionna Therapeutics, Inc. (Nasdaq: SION), a clinical-

Yahoo · Sep 17, 2026

Sionna Therapeutics (SION) Approves 46% Job Cut. Can a New Trial Make its Cash More Productive?

Sionna Therapeutics, Inc. (NASDAQ:SION) announced on September 14 that its board approved an approximately 46% workforce reduction as it concentrates development on SION-451 plus SION-2222 for cystic fibrosis. Sionna Therapeutics, Inc. (NASDAQ:SION) ended the second quarter with approximately $268.3 million in cash, cash equivalents, and marketable securities. Management estimates that the workforce reduction, discontinued investment […]

AI research layers

Interpretive context generated from the platform’s current data sources.

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