Yahoo · Oct 13, 2026
Does NewAmsterdam Pharma’s (NAMS) Genotype-Targeted SPINOZA Trial Reframe Obicetrapib’s Long-Term Alzheimer’s Strategy?
NewAmsterdam Pharma recently dosed the first participant in SPINOZA, a Phase 2b, randomized, double-blind, placebo-controlled trial evaluating its CETP inhibitor obicetrapib in about 400 people with preclinical Alzheimer’s disease. This trial is unusual in that it targets biomarker changes such as plasma p-tau217 in carefully selected ApoE genotype subgroups before symptoms fully develop. We’ll now examine how launching the genotype-stratified SPINOZA Alzheimer’s trial could influence...

