NASDAQ · SYRE

Spyre Therapeutics, Inc.

Healthcare · Biotechnology

$95.51

Up+$3.76 (+3.94%)

Updated Nov 3, 2026, 11:36 PM

SID Score

6.1/10

Composite research score

Smart Money

—

Institutional and insider signal

Market cap: 2.07B
P/E ratio: -79.77
Dividend yield: 0.00%
52-week range: $39.00 – $110.18
Volume: 753.08K
Avg. volume: 928.45K

Price performance · SYRE

SYRE price history

1M range · 21 trading sessions · Daily adjusted prices

Prices through Nov 2, 2026

Last close: $95.51
Period change: +3.01%
Period low: $78.63
Period high: $99.75

Daily close

View OHLC price history

SYRE OHLC price history, latest 40 sessions
Date	Open	High	Low	Close	Volume
Nov 2, 2026	$97.11	$98.13	$93.82	$95.51	753.08K
Oct 30, 2026	$96.78	$98.96	$94.68	$96.56	661.13K
Oct 29, 2026	$99.71	$100.42	$97.95	$98.96	567.64K
Oct 28, 2026	$98.39	$100.14	$97.55	$99.75	724.55K
Oct 27, 2026	$93.00	$99.24	$92.37	$99.045	944.93K
Oct 26, 2026	$91.54	$94.19	$90.35	$92.91	637.18K
Oct 23, 2026	$90.705	$91.90	$88.69	$90.33	503.01K
Oct 22, 2026	$92.95	$94.565	$91.27	$92.33	802.95K
Oct 21, 2026	$92.78	$95.17	$92.315	$92.95	1.15M
Oct 20, 2026	$85.12	$93.2199	$85.075	$91.40	1.71M
Oct 19, 2026	$82.29	$86.05	$80.94	$84.72	1.27M
Oct 16, 2026	$80.21	$80.52	$78.125	$79.90	1.27M
Oct 15, 2026	$76.87	$80.88	$76.87	$80.10	1.15M
Oct 14, 2026	$80.13	$82.45	$77.95	$78.63	1.62M
Oct 13, 2026	$85.12	$85.32	$80.45	$80.45	1.44M
Oct 12, 2026	$86.30	$86.62	$84.21	$85.90	873.91K
Oct 9, 2026	$79.90	$86.22	$78.7301	$85.69	1.12M
Oct 8, 2026	$79.58	$80.91	$77.05	$79.90	2.33M
Oct 7, 2026	$78.91	$82.22	$78.00	$80.85	2.72M
Oct 6, 2026	$92.08	$92.08	$79.36	$80.11	4.25M
Oct 5, 2026	$93.02	$95.01	$89.49	$92.72	642.86K

Latest SYRE news

The latest Smart Investors Daily articles mentioning SYRE.

earningsNov 2, 2026

Spyre Therapeutics, Inc. (SYRE) Set to Report Q3 Earnings on November 03, 2026

sec filingOct 8, 2026

Spyre Therapeutics, Inc. (SYRE) Reports Material Event to SEC

analystAug 11, 2026

BTIG Reiterates Buy Rating on Spyre Therapeutics, Inc. (SYRE)

Latest SYRE news

The latest Smart Investors Daily articles mentioning SYRE.

SYRE research

SEC Filings

Recent regulatory filings and source documents.

SEC filing history

Open a filing to view the original source document.

SYRE SEC filings
Filed	Form	Description	Accepted	Document
Oct 2, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Oct 2, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Oct 2, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Sep 3, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Sep 3, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Sep 3, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Aug 10, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Aug 5, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Aug 5, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jul 2, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jul 2, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jul 2, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jun 26, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jun 23, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jun 23, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
May 8, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
May 1, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
May 1, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
May 1, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Apr 3, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Apr 3, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Apr 3, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Mar 3, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Mar 3, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Feb 4, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jan 23, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jan 13, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jan 13, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jan 13, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jan 13, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jan 6, 2026	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Dec 3, 2025	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Nov 5, 2025	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Sep 3, 2025	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jun 2, 2025	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jun 2, 2025	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jun 2, 2025	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jun 2, 2025	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jun 2, 2025	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jun 2, 2025	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jan 17, 2025	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jan 17, 2025	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jan 17, 2025	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jan 17, 2025	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Jan 14, 2025	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Nov 8, 2024	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Oct 28, 2024	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Oct 1, 2024	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source
Sep 5, 2024	4	Form 4 - Statement of changes in beneficial ownership of securities	—	Open source

Filed

Form

Description

Accepted

Document

Oct 2, 2026